CORRELATION BETWEEN IMMUNE REACTIVITY AND FAT-CARBOHYDRATE METABOLISM - EFFECT OF PHENFORMIN

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 22  (2) , 13-17
Abstract
Decreased immunological reactivity (skin tests and rosette-formation) in oncological patients is associated with a decreased sensitivity to dexamethasone suppression of cortisol; an increased serum concentration of 11-oxycorticosteroids, triglycerides, cholesterol and .beta.-lipoproteins; and decreased glucose tolerance. The use of phenformin for 3 mo. in atherosclerosis patients considerably increased the phytohemagglutinin-stimulated lymphocyte blast transformation index and the number of rosette-forming cells. These effects were associated with normalization of lipid metabolism indices.

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