SERUM LEVELS AND BIOCHEMICAL CHARACTERIZATION OF OESTRADIOL-17β DEHYDROGENASE IN UMBILICAL CORD BLOOD
- 1 January 1975
- journal article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 64 (1) , 103-109
- https://doi.org/10.1677/joe.0.0640103
Abstract
SUMMARY: The properties of the enzyme oestradiol-17β dehydrogenase from human umbilical cord serum have been compared with those of oestradiol-17β dehydrogenase present in the maternal peripheral blood. On the basis of studies on stability, specificity, optimum pH, rate of enzymic reaction and Km determinations it can be concluded that oestradiol-17β dehydrogenase in the umbilical cord arteries has an activity between 5 and 15 times higher than in the umbilical cord vein and about 65% of the activity of the enzyme present in the maternal peripheral blood. The present results strongly suggest that in pregnancy the enzyme oestradiol-17β dehydrogenase is elaborated not only by the placenta but also by the foetus.Keywords
This publication has 0 references indexed in Scilit: