Replacement of H2O by D2O in capillary zone electrophoresis can increase resolution of peptides and proteins
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 3,p. 196-198
- https://doi.org/10.1039/c39910000196
Abstract
Water (H2O) based buffer solutions are generally used in capillary zone electrophoresis (CZE) for the separation of peptides and proteins; the replacement of H2O by D2O in the supporting electrolyte (pH, pD ca. 7.8) contributes to the suppression of electroosmotic flow, mainly due to the higher viscosity of D2O and can result in enhanced resolution of substrates without the use of additives.Keywords
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