EFFECTS OF PROGESTERONE ON CHEMOSENSITIVITY IN NORMAL MEN

  • 1 January 1978
    • journal article
    • research article
    • Vol. 92  (2) , 262-269
Abstract
Progesterone administration increases .ovrhdot.VE [resting minute ventilation] in man, but its effects on ventilatory response to hypercapnia and hypoxia have not been well documented. Accordingly, .ovrhdot.VE, HVR [hypoxic ventilatory response] and HCVR [hypercapnic ventilatory response] were measured during placebo and MPA [medroxyprogesterone acetate] administration in 11 normal men. The effect of MPA (20 mg orally q [every] 8 h for 32 h) on T.degree. [body temperature], metabolic rate (.ovrhdot.VO2 [O2 uptake] and .ovrhdot.VCO2 [CO2 production]) was also determined. With MPA, T.degree. rose 0.4.degree. C .+-. 0.008 (SEM [standard error of the mean]) (P < 0.001), .ovrhdot.VE increased 0.46 .+-. 0.16 l/min (P < 0.01), and .ovrhdot.VO2 and .ovrhdot.VCO2 did not change significantly. HCVR (measured under hyperoxic conditions during rebreathing) increased significantly (P < 0.01) from 2.9 .+-. 0.33 l/min per mm Hg (placebo) to 4.0 .+-. 0.29 (MPA). HVR was measured as the shape parameter A, so that when A increased, HVR was augmented. During MPA, HVR increased from A = 132 .+-. 19.1 to 179 .+-. 20.5 (P < 0.02). MPA [60 mg] daily in normal men increase VE and chemosensitivity as measured by the ventilatory response to hypercapnia and hypoxia.

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