Allergic Rhinitis and Intravascular Aggregation of Blood Cells

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Abstract
It is well known that intravascular aggregation of blood cells occurs in all sorts of tissue trauma including antigen-antibody reaction. Judging from the special architecture of the fine vasculature of the nasal mucosa, sludge of blood should readily occur in certain pathological conditions, such as hay fever. Dextran of low molecular weight, Rheomacrodex®, has proved an effective inhibition of intravascular aggregation. In the present investigation injection of this agent was found to decrease the severity and duration of the reaction of the nasal mucosa to pollen, as measured by the difference in airway resistance. The findings suggest that intravascular aggregation in the vascular network in the nasal mucosa may be a component of importance in allergy and infections and if left untreated it may result in pathological changes of the mucosa, because of anoxic damage to the tissue.