Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine
- 1 February 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 283 (5750) , 826-831
- https://doi.org/10.1038/283826a0
Abstract
The Abelson murine leukaemia virus protein (P120) can become phosphorylated in vitro by [γ-32P]ATP. The protein has been purified from cell membranes to the point that in specific conditions virtually all of the incorporated 32P is in P120. The reaction is stimulated by Mn2+ and Mg2+ but not Ca2+ and is very rapid even at 0 °C. The phosphate is linked to P120 at tyrosine, a linkage not previously reported for a phosphorylation reaction. Phosphorylation may be involved in the transforming activity of viruses that cause leukaemia as well as sarcomas.This publication has 25 references indexed in Scilit:
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