Effect of zinc supplementation on serum testosterone level in adult male sickle cell anemia subjects

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Abstract
Primary testicular failure was documented in adult male subjects with sickle cell anemia. The occurrence of Zn deficiency was reported suggesting that androgen deficiency may be related to Zn deficiency in such patients. Data is presented with respect to the effect of oral Zn supplementation on serum testosterone levels in adult male patients with sickle cell anemia. An increase in serum testosterone, neutrophil Zn, and neutrophil alkaline phosphatase activity was observed in the Zn-supplemented group compared with the group on placebo. Body weight increased and serum lactic dehydrogenase activity decreased in response to Zn supplementation. Androgen deficiency in adult male subjects with sickle cell anemia evidently is correctable with Zn supplementation, the determination of neutrophil Zn and alkaline phosphatase activity in the neutrophils may be utilized as good indicators of body Zn status in such subjects.

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