Synthesis of lipidic amino acid and dipeptide inhibitors of human platelet phospholipase A2
- 1 August 1996
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 48 (2) , 160-166
- https://doi.org/10.1111/j.1399-3011.1996.tb00827.x
Abstract
Phospholipases A2 (PLA2s) catalyze the hydrolysis of glycerophospholipids at the sn-2 position, and their inhibition is considered a rational approach for the prevention and treatment of inflammation. A number of amides and esters of alpha-amino acids with saturated linear side chains, esters of alpha-amino alcohols and derivatives of lipidic peptides were prepared and tested against secreted humal platelet phospholipase A2. Among the compounds tested the amides of free amino acids with long-chain amines presented the highest in vitro inhibitory activity.Keywords
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