Practical Possibilities for Detection of Linkage in Man

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Abstract
Examination of the practical possibilities of detecting linkage, given various numbers of marker systems, and assuming various total lengths of the genome, was carried out. In a simulation experiment by means of an electronic computer, it was demonstrated that with the present number of about 16 useful marker systems there is reason to expect one or more cases of interlinkage in addition to the single one which has been discovered. Even moderate gains in the number of marker systems imply considerable improvements in our possibilities for detection of linkage. Yet even with 90 marker systems the coverage of the genome would be far from satisfactory, the most likely situation leaving still one chromosome unmarked and the probability of readily detectable interlinkage with an additional system still not close to unity.