The Interval Between Irradiation and Bone-marrow Transplantation

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Abstract
An improved 30-day survival was found in CBA mice treated with rat bone marrow if the cells were injected about 24 hours instead of a few hours after a lethal dose of total-body irradiation. No change of mortality was found in C57BL and F1 hybrid mice treated in the same way with rat bone marrow; both the immediate and delayed treatment resulted in a high percentage survival. A further delay of injection beyond 24 hours caused a progressive decrease of 30-day survival. Mice irradiated with a median lethal dose of x-rays showed a better 30-day survival if homologous or heterologous bone-marrow treatment was delayed for 24 hours after irradiation. The effect was most evident in C57BL mice. Occurrence of donor cells in the blood of the chimeras was studied. A 24-hour interval between irradiation and treatment had no significant effect on the number of cells needed for protection.