Association of two tumour necrosis factor gene polymorphisms with the incidence of severe intraventricular haemorrhage in preterm infants
Open Access
- 1 July 2005
- journal article
- letter
- Published by BMJ in Journal of Medical Genetics
- Vol. 42 (7) , 604-608
- https://doi.org/10.1136/jmg.2004.021378
Abstract
Focussing on neonatal morbidity, neither the development of chronic lung disease of prematurity12 nor necrotising enterocolitis13 were correlated to genotype distribution of the TNFα gene, whereas the development of intraventricular haemorrhage (IVH) was correlated to the −308 promoter region polymorphism of the TNFα gene.12 Genetic determination of the individual inflammatory response may influence the susceptibility to poor outcome after systemic infection or severe tissue damage.8, 9, 14Keywords
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