Expansion of B Cells Is Necessary for the Induction of T-Cell Tolerance Elicited through the Anterior Chamber of the Eye
- 31 July 2007
- journal article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 144 (4) , 343-346
- https://doi.org/10.1159/000106461
Abstract
Antigens injected into the anterior chamber (AC) of the eye induce a form of peripheral immune tolerance termed anterior chamber-associated immune deviation (ACAID). ACAID is initiated by F4/80+ ocular antigen-presenting cells (APC) which capture ocular antigens and migrate to the spleen where they transfer antigenic peptides to B cells, which act as ancillary APC for the induction of T-regulatory cells (T(reg)) that inhibit delayed-type hypersensitivity (DTH) responses. Here we show that ocular-like APC induce the expansion of tolerogenic splenic B cells. Furthermore, we show that inhibiting B-cell proliferation with either mitomycin-c or gamma-irradiation abolishes the ability of B cells to induce T(reg). To our knowledge, this is the first study to report that B-cell proliferation is needed for B-cell-induced T-cell tolerance.Keywords
This publication has 10 references indexed in Scilit:
- Peripheral Tolerance Via the Anterior Chamber of the Eye: Role of B Cells in MHC Class I and II Antigen PresentationThe Journal of Immunology, 2006
- See no evil, hear no evil, do no evil: the lessons of immune privilegeNature Immunology, 2006
- The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral toleranceThe Journal of Experimental Medicine, 2005
- Splenic B Cells Act as Antigen Presenting Cells for the Induction of Anterior Chamber-Associated Immune DeviationInvestigative Opthalmology & Visual Science, 2003
- CD25+, interleukin‐10‐producing CD4+ T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eyeImmunology, 2003
- Critical role of B cells in the development of T cell tolerance to aeroallergensInternational Immunology, 2002
- Long-Term Survival of Corneal Allografts Is Dependent on Intact CD1d-Reactive NKT CellsThe Journal of Immunology, 2002
- Ocular Immune Privilege Promoted by the Presentation of Peptide on Tolerogenic B Cells in the Spleen. II. Evidence for Presentation by Qa-1The Journal of Immunology, 2001
- Splenic B cells are required for tolerogenic antigen presentation in the induction of anterior chamber‐associated immune deviation (ACAID)Immunology, 1998
- Abortive Proliferation of Rare T Cells Induced by Direct or Indirect Antigen Presentation by Rare B Cells In VivoThe Journal of Experimental Medicine, 1998