Acute Stroke — On the Threshold of a Therapy?

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Abstract
Ischemic stroke may occur with sudden cruelty and, when not fatal, may deplete the resources of the patient, family, and community. The most effective treatments are directed at the underlying causes of the initial ischemic event, the prevention of recurrence, and the reduction of potential risk factors, but they do little for the stroke itself. The majority of ischemic strokes, roughly 80 percent, result from thromboembolic or atherothrombotic processes. This underscores the fact that stroke is a vascular disorder with neurologic consequences, and provides a basis for the use of antithrombotic agents as therapy. The idea of using plasminogen activators . . .