The Early Retention, Excretion and Distribution of Injected Einsteinium Citrate in Beagles

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Abstract
The excretion, retention and tissue distribution of einsteinium has been studied during a period of up to about 8 weeks following the intravenous injection of 253Es citrate into six young adult beagles. Although the first day's urinary excretion by two of these animals was about three and six times the average of the other four dogs, excretion of the 252Cf contaminant in the injection solution by these same individuals was also much higher. The ratio of excreted Cf to excreted Es in the first day's urine averaged 0.68 for all six dogs and was 0.66 and 0.72 in the two animals which excreted an abnormally high fraction of their injected Es. We have never seen previously such anomalous excretion within any group of beagles injected with Cf, Cm, Am ar Pu. Of the other transuranium elements which we have studied, Es appears to most closely resemble Cf in its excretion, retention and tissue distribution. The 253Es concentration of exsanguinated tissues was about equal in skeleton and liver, the two tissues of highest concentration. Thyroid concentration was about 1/4 to 1/3 that of the skeleton.

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