Role of Zinc in Interleukin 2 (IL‐2)‐Mediated T‐Cell Activation
- 1 May 1990
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 31 (5) , 547-552
- https://doi.org/10.1111/j.1365-3083.1990.tb02805.x
Abstract
In a serum‐free culture containing no zinc, zinc enhanced the proliferation of T cells in response to interleukin 2 (lL‐2), and also the in vitro production of lL‐2 by T cells. Although the lymphocyte proliferation was partially inhibited by anti‐IL‐2 antibodies, it was completely inhibited by anti‐IL‐2 receptor (CD25) antibodies. A Scatchard plot analysis showed that zinc induced the expression of high‐affinity receptors for IL‐2 on lymphocytes. The results indicated that zinc may be essentially required for IL‐2‐mediated T‐cell activation.This publication has 17 references indexed in Scilit:
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