Beta-Cell Deficiency, Insulin Resistance, or Both?

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Abstract
Non-insulin-dependent diabetes (Type II, or maturity-onset diabetes) remains a popular topic in biomedical science because of its prevalence, morbidity, and undefined pathophysiologic aspects. Several general facts about the disorder have been known for decades, but have recently been underscored again in studies of the homogeneous population of Pima Indians by members of the National Institute of Diabetes and Digestive and Kidney Diseases in their unit in Phoenix, Arizona.1 One general observation is that obesity and overeating play very important parts; another, more important one, is that there is a correlation between the disease and increasing age.Numerous studies around the . . .