CYTOLOGICAL AND CYTOCHEMICAL CHANGES IN LIVERS OF WHITE MICE FOLLOWING INTRAPERITONEAL INJECTIONS OF DNA PREPARATIONS FROM BREAST CANCERS OF AGOUTI C3H MICE

Publisher Website
Google Scholar
Abstract
Livers of white BALB/C and CF1 mice show cytological and cytochemical alterations after repeated intraperitoneal injections of deoxyribonucleic acid (DNA) prepared from breast cancers of agouti C3H mice. The livers show foci of abnormally large cells containing large nuclei and large PAS-positive nucleoli. There is a decrease of the glycogen in the liver cytoplasm and an increase in the amounts of DNA in the liver nuclei. These altera- tions were not present in livers of control mice or mice similarly injected with DNA derived from spleen or livers of the same C3H mice.