RECENT RESULTS IN THE FIELD OF THE ANTI-TUMOR ALKALOIDS OF THE VINBLASTINE GROUP - BIOCHEMICAL-STUDIES

  • 1 January 1979
    • journal article
    • research article
    • Vol. 173  (2) , 414-424
Abstract
Studies on the interaction between vinblastine-like alkaloids and their receptor, i.e., tubulin, are reported. They shed some light on the structure-activity relationships in this medicinally important series: the configuration at C14 and C16, as well as the presence of the methoxycarbonyl group on C16 seem to play an essential role in the determination of biological activity. A new analogue, detected by its specific behavior with tubulin, was found in vivo to be as active and less toxic than vinblastine.

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