ENANTIOTOPICALLY SELECTIVE OXIDATION OF 1,3-DIOLS WITH A MICROORGANISM
- 5 November 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 8 (11) , 1379-1380
- https://doi.org/10.1246/cl.1979.1379
Abstract
Microbial oxidation of 2-methylpropane-1,3-diol (1a) proceeded with distinction of pro-(R) and pro-(S) hydroxymethyl groups resulting in the formation of β-hydroxyisobutyric acid (2a) of high optical purity. 2-Ethyl and 2-isopropyl derivatives (1b, c) were also oxidized to give the corresponding hydroxy acids (2b, c), but the optical yields were low.Keywords
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