Advanced colorectal cancer: ESMO Clinical Practice Guidelines for treatment

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Abstract
In 2006 there were 412 900 new cases of colorectal cancer (CRC) in Europe. This is 12.9% of all cancer cases. CRC was responsible for 217 400 deaths in Europe in 2006. This represents 12.2% of all cancer deaths. Approximately 25% present with metastases at initial diagnosis and almost 50% of patients with CRC will develop metastases, contributing to the high mortality rates reported for CRC.

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