The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells
- 16 July 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 217 (4556) , 248-250
- https://doi.org/10.1126/science.7089561
Abstract
The antineoplastic agent adriamycin was coupled to an insoluble agarose support. This material was actively cytotoxic to L1210 cells in culture under conditions in which no free adriamycin could enter the cell. It is concluded that an agent whose principal target was previously thought to be DNA can exert its cytotoxic action solely by interaction at the cell surface.This publication has 7 references indexed in Scilit:
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