Sequence Effect of Irinotecan and Fluorouracil Treatment on Pharmacokinetics and Toxicity in Chemotherapy-Naive Metastatic Colorectal Cancer Patients

1 August 2001

journal article
clinical trial
Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology

Vol. 19 (15) , 3456-3462
https://doi.org/10.1200/jco.2001.19.15.3456

Abstract

PURPOSE: To investigate the sequence effect of irinotecan and a 48-hour infusion of fluorouracil (5-FU) modulated by leucovorin (LV) on the plasma pharmacokinetics of irinotecan and its metabolites...

Keywords

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