Sex and Alcohol: A Second Peek

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Abstract
During 1974, the Journal published two complementary editorials that discussed the pathogenesis of feminization of alcoholic men.1 , 2 In the first, Adlercreutz described the role of the liver in converting androgens to estrogens, in interconverting weak and potent estrogens, and in performing estrogen conjugation, detoxification and excretion.1 He reviewed the changes in estrogen metabolism that were known to occur in cirrhosis, and concluded that many of the signs of hyperestrogenization observed in alcoholic men, and in those with cirrhosis of diverse causes, could be explained by liver disease per se. After the editorial was published, it was reported that an increased . . .