On the Relative Efficacy of Emetine in Intestinal and Hepatic Amebiasis

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Abstract
Injn. of emetine into rabbits was followed by a relatively high drug concn. in the liver for more than a month, whereas the level in the intestine was always much lower and became undetectable after 4 days. The findings of a high concn. and prolonged presence of emetine in the liver and a low concn. and transient presence of the drug in the intestine are proposed as the explanation for the efficacy of emetine in amebic liver disease and the drug''s failure in amebic intestinal disease in man.