SYNTHESIS AND OPIATE ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH VARIOUS CHAIN LENGTHS
- 1 July 1978
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 12 (1) , 42-46
- https://doi.org/10.1111/j.1399-3011.1978.tb02866.x
Abstract
The synthesis of βh‐endorphin* ‐(1–15), ‐(1–21), ‐(1–26), ‐(1–28) and ‐(1–29) have been accomplished by the solid‐phase method. The opiate activities of the peptides were measured in the guinea pig ileum assay. Their relative potencies were βh‐endorphin (βh‐EP), 1.00; Met‐enkephalin, 0.25; βh‐EP‐(1–15), 0.17; βh‐EP‐(1–21), 0.46; βh‐EP‐(1–26), 0.48; βh‐EP‐(1–28), 0.89; βh‐EP‐(1–29), 1.04.Keywords
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