BROMOBENZENE HEPATOTOXICITY IN LEAD PRETREATED RATS

1 January 1976

journal article
research article

Vol. 15 (1) , 121-133

Abstract

The levels of hepatic GSH [glutathione] in animals intoxicated with bromobenzene were studied. A marked decrease of hepatic GSH was observed in poisoned rats. Such decrease was prevented by previous administration of lead nitrate, an inhibitor of DMES [drug-metabolizing enzyme system]. In the rats treated with lead nitrate alone a rise in hepatic GSH was observed. Such protection was further observed by histological examination. The mechanism of protection exerted by lead nitrate against bromobenzene intoxication is discussed.

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