Reduction in multiresistant nosocomial infections in neonates following substitution of ceftazidime with piperacillin/tazobactam in empiric antibiotic therapy
- 1 October 2003
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 92 (10) , 1205-1207
- https://doi.org/10.1080/08035250310005297
Abstract
Aim: To evaluate the effect of a change in antibiotic protocol on pathogens that cause neonatal sepsis. Methods: Suspected sepsis was treated with amikacin together with ceftazidime in 1995–1998 and piperacillin/tazobactam in 1999–2002. Results: The annual rate for Klebsiella sepsis fell from 2.5 to 0.45 cases per 1000 admission days (p= 0.0001) between the two periods studied. Conclusion: The change from ceftazidime to piperacillin/tazobactam is associated with a decrease in the incidence of Klebsiella sepsis.Keywords
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