Vitamin C studies in the rat. The effect of selenium dioxide, sodium selenate and tellurate

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Abstract
Rats with symptoms of selenium and tellurium poisoning show marked decreases in the vit. C content of the liver and adrenals. The production of oxidized glutathione by selenium salts, in contrast to the stable complex which sulphydryl compounds form with the cations of heavy metals, may account for the decrease in ascorbic acid which is observed in vitro even when there is an inhibition of the reduction of the selenium to the colloidal state. Selenium salts are reduced more readily by ascorbic acid than by glutathione or cystine, but the reverse relationship holds true for Na tellurate.