Chlamydia trachomatis Infection Inhibits Both Bax and Bak Activation Induced by Staurosporine
Open Access
- 1 September 2004
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (9) , 5470-5474
- https://doi.org/10.1128/iai.72.9.5470-5474.2004
Abstract
We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.Keywords
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