A phase II study to assess the efficacy of combined preoperative irinotecan (I)/cisplatin (C) chemotherapy and conformal radiotherapy (RT) followed by surgery for potentially resectable esophageal cancer

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Abstract
4063 Background: Five-year survival for locally advanced esophageal cancer is < 20%. Whereas primary surgery is generally recommended, preoperative chemotherapy-RT (CRT) has shown potential to impact on survival. In combination with RT, I and C appear well tolerated. Efficacy is assessed in this phase II trial. Methods: Eligible patients with squamous cell (SCC) or adenocarcinoma of the thoracic esophagus or gastroesophageal junction, technically resectable, without distant metastases, were treated with induction CRT and a RT boost. I (65 mg/m2) plus C (30 mg/m2) were given weeks 1, 2, 4, 5, 7 and 8 with concurrent RT (40 Gy/20) during weeks 4–8. The RT boost was either conformal (10 Gy) or brachytherapy (5 Gy). After a 4–8 week interval and re-staging, the patients underwent resection. Quality of life (QOL) was evaluated using the FACT-E scale. Results: Twenty-one of a planned 30 patients have been entered, 16 have completed CRT and 14 have had their surgery so far. There were 15 men and 6 women, mean ag...

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