A Quantitative In Vivo Comparison of Six Contrast Agents by Digital Subtraction Angiography

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Abstract
Digital subtraction angiography (DSA) technology can now visualize many significant arterial structures from i.v. injections of contrast media. Image quality of these DSA studies is related to contrast agent enhancement. A study was done to compare contrast agents of differing I concentration, viscosity and osmolarity. A technique is described that utilizes a scanned projection digital radiographic system to compare quantitatively degrees of intra-arterial opacification after the administration of 6 i.v. contrast agents: iothalamate (at 4 different concentrations and in combinations with 2 different cations), diatriazoate and ioxaglate. The quantitative arterial enhancement was compared in dogs utilizing an extraperiod latin-square multiple change-over clinical trial design. The contrast agents span a range of organically bound I from 282 to 480 mg I/ml. When rate and volume of contrast agent injected are held constant, intra-arterial opacification is directly a function of the I concentration (mg I/ml) of the agent injected, while osmolarity and viscosity have no effect on opacification. These studies support the use of agents with high I concentration for maximum vascular visualization.

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