Induction of Labor in Intrauterine Fetal Death with 16-Phenoxy-Prostaglandin-E2-Methylsulfonylamide (Sulprostone) – Effects on Uterine Contractility, Coagulation and Kallikrein-Kinin Systems
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in Gynecologic and Obstetric Investigation
- Vol. 29 (4) , 269-272
- https://doi.org/10.1159/000293332
Abstract
Thirty-two patients with intrauterine fetal death after the 20th week of pregnancy were treated with 1–3 intramuscular injections of 500 mg of 16-phenoxy-PGE2-methylsulfonylamide (sulprostone). Intrauterine pressure records demonstrated onset of contractions within 20 min of injection and all women aborted-delivered after in mean 11 h (4–31 h). No effect on routine hematologic and plasma parameters, kallikrein-kinin and factor XII systems was observed. It is concluded that 16-phenoxy-PGE2-methylsulfonylamide is an effective and safe oxytocic agent for the induction of labor in case of intrauterine fetal death with minimal effects on the coagulation system.Keywords
This publication has 1 reference indexed in Scilit:
- DISTRIBUTION OF PROSTAGLANDINS E2 AND F2α WITHIN THE FOETOPLACENTAL UNIT THROUGHOUT HUMAN PREGNANCYJournal of Endocrinology, 1976