Examination of an antibiotic produced by coagulase-negative staphylococci isolated from the bovine udder

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Abstract
Summary: An antibiotic produced by coagulase-negative staphylococci isolated from the bovine udder was examined by deferred antagonism tests and its inhibitory properties compared with those of other staphylococci. While inhibiting the growth of representative phage types of bovine pathogenic staphylococci, its activity against corynebacteria was more restricted than that of Staphylococcus aureus NCTC 6507 and 8004. Only minimal amounts of inhibitory substance were produced in liquid media, larger amounts were produced on solid media and the incorporation of a blood plasma factor further increased production. The inhibitory substance resisted treatment with pepsin and trypsin and withstood boiling for 30 min. Its characters in relation to inhibitory substances produced by other staphylococci are discussed.