Clofibrate-Induced Muscle Damage with Myoglobinuria and Cardiomyopathy

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Abstract
To the Editor: A clofibrate-induced "acute muscular syndrome" has been reported in patients treated for hyperlipidemia with or without chronic renal failure.1 2 3 4 In 1970 a 16-year-old boy treated for diabetes insipidus with vasopressin as a nose spray was re-evaluated because of polyuria, fever and eosinophilia of the blood (count of 35 per cent) and bone marrow. Vasopressin spray was stopped. Eosinophilia and fever disappeared over the ensuing two weeks. Polyuria developed again, with maximum excretion of about 8 liters daily. Because earlier treatment with chlorpropamide caused severe hypoglycemia, clofibrate in a dose of 4 X 500 mg daily was . . .