Chemical Approach to Contact Dermatitis Caused by Household Products. VIII. UV Absorber Tinuvin P in Polyurethane Elastomers for Fabric Products.

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Abstract
A case of contact dermatitis from a T-shirt was reported. The patient reacted to the polyurethane elastomer (PUE) tape used in the T-shirt, Tinuvin P which is a benzotriazole-type UV absorber, and one of 5 brands of commercially available PUE fibers. The analytical procedures for the determination of benzotriazole-type UV absorbers (Tinuvin P, 234, 326, 327, 328 and 329) were as follows : 1) extraction by shaking with a mixture of acetone : chloroform (1 : 1) at room temperature ; 2) fractionation by column chromatography on silica gel by using hexane, dichloromethane, ethyl acetate and methanol as eluting solvents ; 3) qualitative and quantitative analyses by gas chromatography (GC), GC-mass spectrometry (GC-MS) and high performance liquid chromatography (HPLC). Chemical analysis revealed that Tinuvin P was contained in the causative PUE tape and one brand of PUE fiber showing the positive patch test reaction at the concentration of 9150 and 3110 μg/g, respectively. In addition, another brand of PUE fiber with the negative patch test reaction contained Tinuvin 327 (3230 μg/g) and Tinuvin 328 (3200 μg/g). From these results, it was clarified that Tinuvin P in the PUE tape used in the causative T-shirt was a causative chemical in this case and Tinuvin P was present in a brand of commercially available PUE fibers.

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