INHIBITION OF MITOCHONDRIAL-DNA SYNTHESIS BY AFLATOXIN B-1 AND DIMETHYLNITROSAMINE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 21  (2) , 281-293
Abstract
The acute and subchronic effects of aflatoxin B1 and dimethylnitrosamine (DMN) on in vitro incorporation of thymidine-3H into DNA (mt-DNA) from mouse liver mitochondria were studied after single injection or after 1 or 3 mo. of weekly injection. Both carcinogens induced 50% decreases in mt-DNA synthesis acutely, with a 50% decrease in synthesis of high MW mt-DNA. Subchronic administration of aflatoxin B1 inhibited mt-DNA synthesis by 54% with elution profiles similar to the controls. DMN showed only a 29% inhibition of mt-DNA synthesis at one mo. increasing to 55% at 3 mo.

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