In Vitro Activities of ABT-773, a New Ketolide, against Aerobic and Anaerobic Pathogens Isolated from Antral Sinus Puncture Specimens from Patients with Sinusitis
- 1 August 2001
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (8) , 2363-7
- https://doi.org/10.1128/aac.45.8.2363-2367.2001
Abstract
The comparative in vitro activities of ABT-773 against 207 aerobic and 162 anaerobic antral sinus puncture isolates showed that erythromycin-resistant pneumococcal strains were susceptible to ABT-773 (≤0.125 μg/ml); the MIC at which 90% of the isolates tested were inhibited for Haemophilus influenzae and other Haemophilus spp. was 4 μg/ml; and all Moraxella spp. and beta-lactamase-producing Prevotella species strains were inhibited by ≤0.125 μg/ml. Among the anaerobes tested, only fusobacteria (45%) required ≥4 μg of ABT-773/ml for inhibition. ABT-773 may offer a therapeutic alternative for sinus infections.Keywords
This publication has 17 references indexed in Scilit:
- Influence of Variations in Test Methods on Susceptibility of Haemophilus influenzae to Ampicillin, Azithromycin, Clarithromycin, and TelithromycinJournal of Clinical Microbiology, 2001
- Comparative In Vitro Activities of ABT-773 against 362 Clinical Isolates of Anaerobic BacteriaAntimicrobial Agents and Chemotherapy, 2001
- The in vitro activity of ABT773, a new ketolide antimicrobial agent.Journal of Antimicrobial Chemotherapy, 2000
- In vitro activity of ABT-773 against anaerobic bacteria.European Journal of Clinical Microbiology & Infectious Diseases, 2000
- Comparative In Vitro Activities of ABT-773 against Aerobic and Anaerobic Pathogens Isolated from Skin and Soft-Tissue Animal and Human Bite Wound InfectionsAntimicrobial Agents and Chemotherapy, 2000
- Antimicrobial Treatment Guidelines for Acute Bacterial RhinosinusitisOtolaryngology -- Head and Neck Surgery, 2000
- In Vitro Activity of ABT-773, a New Ketolide, against Recent Clinical Isolates of Streptococcus pneumoniae , Haemophilus influenzae , and Moraxella catarrhalisAntimicrobial Agents and Chemotherapy, 2000
- Resistance to Antimicrobials Used for Therapy of Otitis Media and Sinusitis: Effect of Previous Antimicrobial Therapy and SmokingAnnals of Otology, Rhinology & Laryngology, 1999
- Comparative In Vitro Activities of Four Macrolides at Two pH Values Against Gram-negative Anaerobic Rods other than theBacteroides fragilis GroupAnaerobe, 1999
- Surveillance of antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States in 1996–1997 respiratory seasonDiagnostic Microbiology and Infectious Disease, 1997