Asymmetric synthesis of 2-azido-1-arylethanols from azido aryl ketone–β-cyclodextrin complexes and sodium borohydride in water
- 1 January 2001
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 19,p. 1974-1975
- https://doi.org/10.1039/b106736m
Abstract
β-Cyclodextrin catalyses for the first time the asymmetric reduction of α-azido aryl ketones to corresponding alcohols of great significance using sodium borohydride in water. The azido group appeared to be the best fit among various groups studied. This asymmetric reduction using water as solvent overcomes many of the drawbacks in the existing methodologies.Keywords
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