PANCURONIUM IN CAESAREAN SECTION AND ITS PLACENTAL TRANSFER

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Abstract
Pancuronium bromide was used in 49 patients undergoing repeat elective Caesarean section. In 26 patients who received only pancuronium 0.1 mg kg−1, pancuronium was detected in all umbilical venous or arterial samples (0.12 μg ml−1). In 23 other patients who received suxamethonium 1.0 mg kg−1 followed by pancuronium 0.05 mg kg−1, pancuronium was detected in fetal blood 2 min after injection; the concentration of pancuronium in umbilical venous or arterial samples in 14 subjects was 0.08 μg ml−1, and less than 0.05 μg ml−1 in nine subjects. There was no evidence that such concentrations of pancuronium were detrimental to the fetus. The use of suxamethonium before pancuronium resulted in reduction of pancuronium dosage, induction-delivery time, and fetal concentrations of pancuronium, and was associated with better condition of the neonate.

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