Needle-Free Skin Patch Vaccination Method for Anthrax
Open Access
- 1 February 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (2) , 1181-1183
- https://doi.org/10.1128/iai.72.2.1181-1183.2004
Abstract
Three immunizations of mice with recombinant protective antigen (rPA) by transcutaneous immunization (TCI) induced long-term neutralizing antibody titers that were superior to those obtained with aluminum-adsorbed rPA. In addition, rPA alone exhibited adjuvant activity for TCI. Forty-six weeks after completion of TCI, 100% protection was observed against lethal anthrax challenge.Keywords
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