The effects of drugs on circular muscle strips from the isolated ileum of the rabbit

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Abstract
Circular muscle strip preparations were contracted by high concentrations of acetylcholine, methacholine or carbachol, but not by other smooth muscle stimulants. The responses to acetylcholine were antagonized by muscarinic blocking agents but not by ganglion-blocking drugs or local anaesthetics. Anticholinesterases induced violent and prolonged activity which was unaffected by repeated washing, by atropine or by local anaesthetics. The insensitivity to acetylcholine and the anomalous responses to anticholinesterases and to the stimulant drugs are discussed. It is suggested that there is some basic difference between the pharmacological responses of the two layers of the mammalian small intestine.