Treating Tobacco Addiction — Nicotine or No Nicotine?

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Abstract
Nicotine has been the mainstay of pharmacotherapy for tobacco addiction, but other medications, such as the antidepressant drugs bupropion and nortriptyline, are also effective. These antidepressant agents are effective in patients without current depression. Identifying the mechanism by which such drugs help someone quit may increase our understanding of nicotine addiction. The availability of medications that do not contain nicotine provides physicians and other health care workers with new choices and decisions on the optimal approach to smoking cessation in their practices.The results of the first large clinical trial of bupropion as an aid to smoking cessation appear in . . .