Mixed Mania Associated with Tricyclic Antidepressant Therapy in Prepubertal Delusional Depression: Three Cases
- 1 January 1998
- journal article
- case report
- Published by Mary Ann Liebert Inc in Journal of Child and Adolescent Psychopharmacology
- Vol. 8 (3) , 181-185
- https://doi.org/10.1089/cap.1998.8.181
Abstract
This report describes the sudden appearance of mixed mania in three children with delusional depression soon after the commencement of tricyclic antidepressant therapy. The observation is consistent with reports linking psychomotor abnormalities and psychosis in severely depressed juveniles to an increased propensity for manic switching, as well as adult studies that report a greater risk of antidepressant-induced cycling in bipolar compared with unipolar affective illness. The cases described suggest the need for caution when considering tricyclic pharmacotherapy in juveniles with severe depressive disease.Keywords
This publication has 2 references indexed in Scilit:
- The Course of Major Depressive Disorder in Adolescents: I. Recovery and Risk of Manic Switching in a Follow-up of Psychotic and Nonpsychotic SubtypesJournal of the American Academy of Child & Adolescent Psychiatry, 1993
- Bipolar outcome in the course of depressive illnessJournal of Affective Disorders, 1983