Bicarbonate Reabsorption along Renal Tubules.

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Abstract
The stop flow technique allows us to characterize transport systems within the nephron by the concentration pattern developed along the renal tubule during brief ureteral occlusion during osmotic diuresis in dogs. The pattern is caught in rapid serial urine samples on reinstatement of flow. In NaHCO3 loaded dogs under osmotic diuresis we find that bicarbonate and chloride are reabsorbed avidly in a far distal area coincident with Na. Compared to values in free flowing osmotic diuretic urine, concentration of bicarbonate developed in proximal tubules during stop flow remains low at the same point where chloride is relatively elevated. Reabsorption of proximal HCO3 alone does not account for Cl elevation. Cl secretion into and removal of other anions from the proximal fluid is considered.

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