GROWTH OF HUMAN CANCER CELLS IN INTERSCAPULAR BROWN FAT OF RATS

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Abstract
Macroscopic growth of human cancer cell lines J-lll and RPMI-41 occurred frequently in the interscapular brown fat pad (as well as in lungs and certain other organs) following iv [intravenous] inoculation into newborn rats. Tumor growth in this tissue of rats has not been observed previously with either spontaneous or transplanted tumors. HEp 2 cells rarely grew in the fat pad, although they did grow well in lungs and adrenals. Consideration of the anatomical and physiological characteristics of the interscapular fat pad suggests that the local tissue milieu has a greater influence than vascular anatomy on the deposition and growth of the tumor cells in this structure.