Effective Ring-Opening Reaction of Aziridines with Trimethylsilyl Compounds: A Facile Access to β-Amino Acids and 1,2-Diamine Derivatives
- 8 February 2000
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 65 (5) , 1344-1348
- https://doi.org/10.1021/jo9913816
Abstract
Ring-opening reactions of aziridines with trimethylsilyl compounds triggered by tetrabutylammonium fluoride give the corresponding products regioselectively in excellent yield. It provides a facile and efficient procedure for the ring-opening reactions of aziridines and affords a practical access to the synthesis of cyano-, azido-, or chloroamines because of its efficiency and simplicity. The products are easily transformed to vicinal diamines or beta-amino acids.Keywords
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