Role of the High-Affinity Zinc Uptake znuABC System in Salmonella enterica Serovar Typhimurium Virulence
Open Access
- 1 August 2002
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 70 (8) , 4721-4725
- https://doi.org/10.1128/iai.70.8.4721-4725.2002
Abstract
The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.Keywords
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