Calcium antagonists inhibit met-enkephalin immunoreactive material release: in vitro and ex vivo experiments
- 1 February 1990
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 80 (1) , 1-8
- https://doi.org/10.1007/bf01245019
Abstract
Depolarizing stimuli increase the release of neurotransmitter met-enkephalin from rat striatal slices. Bay K 8644, a calcium agonist, significantly enhances the submaximal release of this peptide. Several organic calcium antagonists, including nimodipine, nifedipine, nicardipine, gallopamil and flunarizine, are able to inhibit the potassium-evoked met-enkephalin release both in vitro and ex vivo. The data suggest that the release of this neuropeptide is modulated by calcium antagonist-sensitive calcium channels.This publication has 27 references indexed in Scilit:
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