Superoxide dismutase inhibits the superoxide‐driven Fenton reaction at two different levels
- 3 June 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 185 (1) , 19-23
- https://doi.org/10.1016/0014-5793(85)80732-8
Abstract
Superoxide dismutase (SOD) completely inhibits the damage caused by a ferric-EDTA chelate in the presence of a superoxide-generating system. In this reaction Superoxide is enzymically dismuted to hydrogen peroxide. Since hydrogen peroxide and a ferric-EDTA chelate are themselves a hydroxyl radical-generating system, it follows that SOD must also protect against damage done by this reaction. The ability of SOD to inhibit damage to deoxyribose caused by hydrogen peroxide and a ferric-EDTA chelate is experimentally demonstrated in this paper.Keywords
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