Interactions between segmented polyurethane surfaces and the plasma protein fibrinogen
- 1 March 1977
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 11 (2) , 237-250
- https://doi.org/10.1002/jbm.820110209
Abstract
Surfaces of a segmented polyurethane were varied by casting on poly(ethylene terephthalate) (PET) and glass substrates, and were characterized through infrared‐attenuated total‐reflection spectroscopy (ATR). Surfaces cast on glass substrates showed a higher content of polyether segments, whereas those cast on PET contained a higher relative concentration of aromatic segments. Adsorption, and possible conformational changes of fibrinogen, were found to be more substantial on polymer surfaces having a higher content of polyether segments. It is concluded that the relatively good blood compatibility of segmented polyurethanes is partly due to the presence of peptide‐like bonds on aromatic segments.Keywords
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